Journal of Cytology
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   2003| October-December  | Volume 20 | Issue 4  
    Online since July 30, 2018

 
 
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CASE REPORTS
Hashimoto's thyroiditis - An unusual presentation as cystic solitary nodule - A diagnostic dilemma
Amarjit Singh, SK Kahlon, KS Chahal, Bhupinder Kaur, Jaspreet Kaur
October-December 2003, 20(4):193-195
Hashimoto's thyroiditis presenting as solitary nodule is well documented. We report herewith a case of cystic change in the solitary thyroid nodule, confirmed by histopathology. As such no such case appears to have been documented. The finding of pleomorphic epithelial cells (hurthle cells) in the aspirate of such a cystic nodule of Hashimoto's thyroiditis may create a diagnostic dilemma and erroneous diagnosis of thyroid neoplasm with cystic change may be made if this possibility is not kept in mind.
[ABSTRACT]   Full text not available  [PDF]
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ORIGINAL ARTICLES
Role of FNAC in diagnosis of paediatric head and neck neoplasms
Sanhita Chatterjee, Nandita Basu, Alpana Basu, Dipanwita Nag Roy, Sarbani Chatterjee, Rita Chatterjee, Mamata Guha Mallik
October-December 2003, 20(4):185-188
Head and neck masses in children are common but the spectrum of pathology differs from that in adults. In children the lesions are related to congenital anomalies, inflammation etc are commoner than the primary malignancies unlike that in adults. Primary malignant tumors of head and neck account for about 5% of all neoplasms occurring in children. Suspicious or long standing masses are referred to the otolaryngologist who faces the dilemma of deciding which one requires surgical intervention. It is also very important to exclude the inflammatory masses from the neoplastic ones, as they are often cured by conservative treatment only. Role of FNAC is very important because early diagnosis can be given segregating the masses allowing more rational planning of treatment.
[ABSTRACT]   Full text not available  [PDF]
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CASE REPORTS
Multiple myxoid fibroadenomas of breast - A case report
Sujata Nayak, SC Puranik, VV Holla
October-December 2003, 20(4):204-205
A rare case of multiple myxoid fibroadenomas in a 30 year old female is described. This interesting case illustrates the diagnostic and management dilemmas faced by both pathologists and clinicians. With a histological diagnosis of myxoid fibroadenoma the patient requires further evaluation for cutaneous and cardiac myxomas.
[ABSTRACT]   Full text not available  [PDF]
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ORIGINAL ARTICLES
AgNOR counts in exfoliative cytology smears of preinvasive and invasive squamous epithelial lesions of cervix
Sangeeta Pahuja, Monisha Choudhury, Usha Gupta
October-December 2003, 20(4):177-179
Nucleolar organiser regions (NORs) are chromosomal segments coding for ribosomal RNA. Number of NORs correlates with cellular proliferation and has diagnostic and prognostic value in neoplastic diseases. The study was conducted to evaluate the utility of AgNOR counting in cytology smears of various grades of squamous intraepithelial and invasive lesions of cervix. AgNOR staining was done on 30 cases of preinvasive and invasive malignant epithelial lesions of cervix. AgNOR dots were counted in at least 100 dyskaryotic/malignant cells with the help of camera lucida drawings and mean AgNOR number/nucleus was calculated. We observed that mean AgNOR/nucleus increased with increasing grade of lesion with statistically significant difference between HGSIL and SCC of cervix. Hence AgNORs can be helpful to differentiate preinvasive from invasive squamous epithelial lesions of cervix.
[ABSTRACT]   Full text not available  [PDF]
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CASE REPORTS
Atypical subcutaneous lipomatous tumour: Cytodiagnostic challenge
Supreeta Nayak, Pradeep Umap, Sudhakar K Bobhate
October-December 2003, 20(4):198-200
Atypical Lipomatous Tumour (ALT) is a rare pseudosarcomatous soft tissue neoplasm which presents problems in both its diagnosis and nomenclature. A 45- year old male presented with a large subcutaneous thigh mass of approximately three years duration. Fine Needle Aspiration (FNA) smears revealed mature fat tissue fragments alongwith atypical cells, often multinucleated, which had hyperchromatic, occasionally bizarre nuclei. Based on this pleomorphic cytomorphology, a diagnosis suggesting malignancy was forwarded. But the characteristic histopathologic appearance of the excised tumor coupled with its distinctive clinical presentation established the diagnosis of ALT. On review of the FN AC smears, the false impression created by this entity mimicking malignancy, was recognised and the potential pitfall in its cytodiagnosis realised. The atypical cellular features of the aspirate of ALT can cause a diagnostic dilemma, but awareness of this uncommon condition holds the key to the correct diagnosis.
[ABSTRACT]   Full text not available  [PDF]
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ORIGINAL ARTICLES
Can PAP staining of air dried cervical scrape smears replace the traditional wet fixed smears?
MM Kamal, S Dandige, SM Kawthalkar, HR Kulkarnil, SN Parate, CS Sarodey, SK Bobhate
October-December 2003, 20(4):168-171
An alternative to ‘air drying’ artifacts seen in improperly wet fixed cervico-vaginal smears would be total elimination of fixation in alcohol and allowing the smears to dry in air. The primary objective of this study was to evaluate and compare the cell morphology in rehydrated air-dried smears (ADS) and the conventional wet fixed smears (WFS) and also to study the effect of postponing rehydration of smears. Three hundred and fifty cervical scrape smears were prepared from material collected from 10O patients. First smear from every patient (100) was wet fixed in 95% ethanol. The remaining smears (250) were air-dried and were divided in two groups. Group 1 included 100 ADS that were stained by Papanicolaou staining within three to four hours of collection. Group II included 150 ADS stained after 24 (50), 48 (50) and 72 (50) hours, to see the effect of postponing rehydration of ADS. Rehydration of ADS was done in normal saline for 20-30 seconds, followed by post fixation in 5% glacial acetic acid in 95% ethanol Using a scoring method the cytomorphology seen in ADS was compared with that of WFS for effect on background blood and mucus, nuclear chromatin, nucleolus, cytoplasmic details, overall ease of interpretation of the smear and degree of air drying artifact. The cytomorphology in ADS stained within 3-4 hours was comparable if not superior to that seen in WFS, as shown by the p values that were highly significant for inter-observer agreement and also comparable with the p values of WFS for all the parameters. In Group II cases the details of nuclear chromatin, nucleolus, differentiation of cytoplasm and restoration of its transparency were gradually and significantly lost with postponement of rehydration. However p value for overall ease of interpretation of cytomorphology was significant except for the smears rehydrated at 72 hours. Overall the smears showed no significant drying artifact even when rehydrated at 72 hours. Additional advantages like, reduction in the demand of alcohol and ease of preparing and transport of smears, can promote collection of Pap smears in more number of women especially in the rural areas.
[ABSTRACT]   Full text not available  [PDF]
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A statistical analysis of fine needle aspiration biopsies done in palpable malignant breast lesions
RGW Pinto, Kulwant Singh
October-December 2003, 20(4):189-192
This study represents a statistical analysis and cytohistologic correlation of FNA in palpable malignant breast lesions performed at the FNA clinic of Goa Medical College during a seven-year period. Only the cases where subsequent histologic diagnosis was available were analysed. All the aspirations were performed by the pathologists. Out of a total of 582 cases, cytological diagnosis was malignant in 180 cases (30.9%). Four cases (1.3%) were false negative. There were no false positive cases in the study. A sensitivity rate of 97.8% and a specificity of rate of 100% was obtained for malignancy. Positive and negative predictive value for the diagnosis of malignancy was 100% and 98.6% respectively. Efficiency of the test was 99.1%. FNA specific diagnosis showed an overall agreement of 95.9% for malignant lesions. All these results compare favourably with the best reported in literature. All these factors can help the clinicians in the management of malignant breast lesions.
[ABSTRACT]   Full text not available  [PDF]
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CASE REPORTS
Cytologically diagnosed epithelioid Gastric Stromal Tumour (GIST)
Andleeb Abrari, Meher Aziz
October-December 2003, 20(4):201-203
The patient, a 55 year old male, had suffered repeated instances of unremitting vomiting and episodic epigastric pain. Barium meal revealed a luminally projecting space occupying gastric lesion. Transcutaneous FNAC under sonographic guidance was employed for directly accessing material from the gastric fundal mass. Examination of stained cytosmears led to a diagnosis of epithelioid gastric stromal neoplasm, which was subsequently confirmed on histology.
[ABSTRACT]   Full text not available  [PDF]
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ORIGINAL ARTICLES
Correlation of urinary cytology, bladder washings with histopathology of neoplastic and non-neoplastic lesions of urinary bladder
PR Malur, VM Dhorigol, AS Chandrakanth
October-December 2003, 20(4):172-176
Fifty consecutive patients, presenting with signs and symptoms referable to the urinary tract, that could have been an inflammatory or neoplastic process were studied to evaluate the reliability of urinary cytology against bladder wash cytology, compared with histopathologic study. It is a prospective study over a period of two years. There were 40 men and 15 women between the ages of 17 to 82 years. The voided urine and bladder wash specimens 50 ml each were fixed in equal volume of 2% formal saline. Smears were prepared from the cell sediment for comparison, biopsy specimens from these patients were subjected to histopathologic study. Of the 55 cases, inflammatory lesions (60%) out numbered the malignant lesions (25%). The sensitivity of urine cytology was 90% and 79% for non neoplastic and neoplastic conditions respectively. The sensitivity for bladder wash cytology was found to be 93%. Similarly, the specificity was 79% and 90% for non neoplastic and neoplastic lesions respectively by the urine cytology method, whereas the same by bladder wash cytology was found to be 94%.
[ABSTRACT]   Full text not available  [PDF]
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CASE REPORTS
Fine needle aspiration cytology of sebaceous carcinoma of the eyelid - A case report and discussion of differential diagnosis
Sanjiv Gupta
October-December 2003, 20(4):196-197
Sebaceous carcinomas of the eyelid are uncommon neoplasms. If excised early, the prognosis is good. Therefore, familiarity with their cytological appearance is of paramount clinical importance. We describe cytological appearance of a sebaceous carcinoma of the eyelid and relevant differential diagnosis. A 45 year-old-female presented with a swelling of right upper eyelid. Aspiration cytology showed sheets of cells with abundant foamy cytoplasm and pleomorphic nuclei. Histopathological examination of the excision biopsy specimen was confirmatory.
[ABSTRACT]   Full text not available  [PDF]
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ORIGINAL ARTICLES
Utility of fine needle aspiration cytology in skin tumours
Sanjay Nanaji Parate, Sudhir M Sankalecha, Anshu , Maitreyee Milind Munshi, Sudhakar S Bobhate
October-December 2003, 20(4):180-184
This study was carried out to determine the utility of fine needle aspiration cytology (FNAC) in the diagnosis of skin tumours. 219 cytologically diagnosed fine needle aspirates of skin tumours were studied prospectively over a period of 17 months. Histopathological correlation was done wherever possible. Ill cases of benign and 108 cases of malignant skin tumours were diagnosed. Histopathological correlation, which was available in 135 cases, showed that the accuracy of fine needle aspiration biopsy in making the diagnosis was 97.17%. One false positive and two false negative diagnoses were made in this study. In outpatient departments, FNAC of skin tumours retains its utility as a primary diagnostic modality and follow-up procedure with a high degree of accuracy. While histopathology is the preferred mode of diagnosis of skin tumours, the authors recommend the use of FNAC as an adjunct to biopsy.
[ABSTRACT]   Full text not available  [PDF]
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LETTERS TO THE EDITOR
Cytologic detection of enterobius vermicularis on a routine cervical smear
Ashwini A Wadadekar, Sanjay N Parate, Ajay A Gangshettiwar, SK Bobhate
October-December 2003, 20(4):207-208
Full text not available  [PDF]
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Seminoma mimicking renal cell carcinoma - Diagnosed by FNAC - A case report
Sheeba Riaz, Asha Agarwal, PK Singh, SN Singh
October-December 2003, 20(4):208-209
Full text not available  [PDF]
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Filariasis breast: A report of two cases, an unusual site to be involved
Ishita Pant, PK Singh, SN Singh, Asha Agarwal
October-December 2003, 20(4):206-207
Full text not available  [PDF]
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