Journal of Cytology
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   1995| January-March  | Volume 12 | Issue 1  
    Online since July 19, 2018

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Comparative evaluation of rapid methods of diagnosis in mammary lesions
Loveling K T Thilak, Ramesh Chopra, Prakash Johnson
January-March 1995, 12(1):37-41
Rapid methods of diagnosis were employed in 104 cases of breast lumps and the results of each method were compared with those of paraffin sections. With Fine needle aspiration cytology, accuracy of diagnosis was achieved in 92.3% cases. Imprint cytodiagnosis established the correct diagnosis is 89.1% of the cases. No false positive diagnosis was made with either of these techniques. Frozen sections correctly distinguished between benign and malignant lesions in 100% cases. The use of both the cytological techniques in diagnosis of breast tumours has been compared and discussed.
[ABSTRACT]   Full text not available  [PDF]
  181 3 -
Diagnostic assessment of sputum cytology by saccomanno method and epithelial membrane antigen staining by immunoperoxidase method
Annie John, SK Bobhate, Sanjay N Parate
January-March 1995, 12(1):14-19
In this study a direct comparison was made between the two methods of cytopreparation of sputum, the Saccomanno method and the direct, pick and smear method on 60 cases. The cases which were diagnosed as dysplasias or malignancies were subjected for Epithetial Membrance Antigen staining. On comparing the two methods the adequacy rate of sputum by saccomanno method was 96.66 per cent and where as that of pick smear method was 88.33 per cent. 30 cases were positive for dysplastic and malignant cells on Saccomanno preparation and 24 on direct method. The commonest type of malignancy in our study was squamous cell carcinoma 15 (50%) followed by adenocarcinoma. Out of these 15 cases of squamous cell carcinomas, the direct method could diagnose only 6 cases as squamous cell carcinoma, 6 were diagnosed as dysplasias and 3 were inadequate. One case of squamous metaplasia, one case of dysplasia and 2 cases of adenocarcinoma were negative on direct method, but diagnosed on Saccomanno method of sputum cytology. When subjected to EMA, all cases of dysplasias and malignancies were positive. Thus EMA couid be applied to the sputum smears with dysplasias to rule out the chances of patient going in for malignancy and also for confirmation of malignancy.
[ABSTRACT]   Full text not available  [PDF]
  178 1 -
Fine needle aspiration of prostate - A correlative study with histology and other biochemical parameters
Arvind Rajwanshi, Enam Murshid Khan, Srinivasan Radhika, Surendra K Sharma, Shivyogi R Bhushnurmath, Raje Nijhawan, Pranab Dey
January-March 1995, 12(1):2-8
Per rectal fine needle aspiration cytology of 328 cases prostatic lesions were performed. The lesions included benigh prostatic hyperplasia (201), adenocarcinoma (95), transitional cell carcinoma (1), inflammatory (20). There were 10 cases of granulomatous prostatitis of which 3 were of tuberculous in origin and one was allergic prostatis. Per rectal findings correlated well with cytology. Cy?ohistologic correlation was good except for two false negative cases. Serum acid phosphtase estimation and acid phosphatase staining on smears were of little help. However one case of transitional cell carcinoma was classified on the basis of negative acid phosphtase staining on the smear.
[ABSTRACT]   Full text not available  [PDF]
  174 4 -
Cytology of cystic breast lesions
Roque G W Pinto, Suresh Mandreker, Jude Rodrigues, Francis P Noronha
January-March 1995, 12(1):20-24
1352 FNACs and nipple discharge smears of the breast were performed in females from Jan 1990 to May 1995. Of these, 92 yielded fluid on F NAC, there were 40 breast cysts, 34 inflammatory lesions, 16 galactoceles, and 2 malignancies. Ninety one cases were situated in the breast proper and 1 case was in the axillary tail. The color of the fluids varied from amber, greenish, purulent, milky and serosanguineous to bloody. Out of 42 breast cysts (inflammatory lesions and galactocele excluded), nipple discharge was seen in 2 cases. There were 2 malignant cystic breast lesions, an infiltrating duct carcinoma and primary Squamous cell carcinoma both of which showed bloody to serosanguineous fluid on FNAC and residual mass persisted after repeated aspirations.
[ABSTRACT]   Full text not available  [PDF]
  173 2 -
Fine needle aspiration cytology of malignant cystosarcoma phyllodes a case report with special reference to pitfall at cytology
Bhaskar Mukerjee, N Srinath, Prakash V Path, Annapurna V Dhaded
January-March 1995, 12(1):64-68
Malignant cystosarcoma phyllodes is an uncommon tumour of the breast. It comprises malignant sarcomatous stroma and benign epithelial component, lining cysts or cleft-like spaces within the stroma. It is distinguished from benign cystosrcoma phyllodes by stromal atypia, mitotic figures, large tumour size and infiltrating margins and from fibroadenoma, in having greater stromal cellularity. FNAC diagnosis of malignant cystosarcoma can be made if both stromal cells and benign epithelium are aspirated. However, in the absence of stromal cells, a diagnosis of fibroadenoma is likely to be made. A correct cytological diagnosis is possible, if repeat aspirations and/or four quadrant aspiration biopsy is performed. In all cases however, histology of excised tumour provides for accurate indentification established on well defined criteria.
[ABSTRACT]   Full text not available  [PDF]
  174 0 -
Echinococcosis masquerading as an inquinai lump -- A case report
Shiv Kapur, Manjula Jain, Kulbhushan Logani, S Ashok
January-March 1995, 12(1):77-79
A rare case of solitary subcutaneous Hydatid disease presenting as an inguinal lump is reported. Fine needle aspiration was attempted assuming the lesion to be an inguinal mass. Aspirates revealed Scolices and hooklets of Echinococcus Granulosus. A diagnosis of Hydatid disease was made, which was further confirmed on histopathological examination. The aim of this article is to highlight this rare location of Hydatid cyst.
[ABSTRACT]   Full text not available  [PDF]
  174 0 -
Malignant melanoma presenting as chronic menignitis-cytological diagnosis of cerebrospinal fluid -- A case report
Nichiket S Dixit, Uday B Muthane, P Satishchandra, Anisya V Taly, M Gourie-Devi, A Ghandramuki, SK Shankar
January-March 1995, 12(1):48-51
The sole presentation of a malignant melanoma as carcinomatous meningitises extremely fare. Herein, we report a 17year old patient presenting with features of meningitis who had melanoma cells in the CSF. This patient was initially diagnosed as tuberculous meningitis but a lack of response to specific antituberculous therapy led us to investigate for other causes of meningitis. Repeated examination of the lumbar CSF for malignant cells by cytospin preparation showed abnormal cells containing dark brown pigment. As this pigment could be bleached it was considered to be melanin and not haemosiderin confirming the abnormal cells to be from a melanoma. There was no evidence of a melanoma elsewhere in the body in our patient.
[ABSTRACT]   Full text not available  [PDF]
  167 0 -
Breast cytology
Gita Jayaram
January-March 1995, 12(1):82-86
This review article presents the vast experience of the author in Fine Needle Aspiration Cytologic diagnosis of various lesions of the breast. A lump in the breast is a most commonly presented symptom in the routine surgical practice. This article highlights the important points that should be borne in mind in Cytological diagnosis.
[ABSTRACT]   Full text not available  [PDF]
  165 2 -
Solid and papillary epithelial neoplasm of the pancreas diagnosed by fine needle aspiration -- A case report
CV Raghuveer, MA Mala, Muktha R Pai, Devadas Hegde, Sunanda U Kini
January-March 1995, 12(1):58-59
Solid and papillary epithelial neoplasm of the pancreas is a rare, distinctive clinico pathological entity. Its accurate preoperative diagnosis is very useful in giving a good prognosis since it is amenable for surgical treatment. FNAC could be employed for this purpose.
[ABSTRACT]   Full text not available  [PDF]
  165 0 -
Infiltrating duct carcinoma in cystosarcoma phylloides at fine needle aspiration cytology -- A case report
Subhash K Gupta, Kanchan Saini, Rakesh K Vashishta
January-March 1995, 12(1):60-63
Cytological features of a rare case of recurrent cystosarcoma phylloides whose epithelial component underwent malignant change and metastasized to the axillary lymph node, is reported.
[ABSTRACT]   Full text not available  [PDF]
  164 0 -
Solid and papillary epithelial neoplasm of pancreas -- A case report with role of fine needle aspiration cytology in diagnosis, with special emphasis on stromal changes
Suash Sharma, Neeta Kumar, Kusum Verma
January-March 1995, 12(1):52-57
Solid and Papillary epithelial neoplasm (SPENP) of pancreas is a rare malignant lesion of pancreas occuring more commonly in the second and third decades, generally in the body and tail of pancreas and has a favourable outcome following surgical resection. We report one such case in a 8 year old girl who presented with a relatively freely mobile mass in the right hypochondrium and not associated with jaundice. On ultrasound and MRI scans, this retroperitoneal mass was not seen in relation to any organ. Despite her unusual age, location, ambiguous clinical and radiological features, the pre-operative diagnosis was made on FNA alone. The diagnosis was based on the presence of papillary, papillary-micro-acinar and acinar fragments showing monomorphic small cells with round to oval nuclei with fine chromatin, cytoplasmic vacuolations and inclusions with characteristic stromal changes.
[ABSTRACT]   Full text not available  [PDF]
  164 0 -
Cytohistopathological study of helicobacter pylori in endoscopic biopsies
Madhu M Goel, Padam K Agrawal, Shailja Shukla, Sarita Tandon, Mam Chandra
January-March 1995, 12(1):29-33
Eighty eight Endoscopic gastric biopsies, 180 imprint and 190 brush smears from eighty eight patients clinically suspected to have acid pepsin disease were reviewed and compared for presence of Helicobacter pylori. Histologic diagnosis of these cases were; chronic gastritis (55), gastric carcinoma (7), and normal gastric mucosa (26). Besides routine haematoxylin and eosin stain on smears and sections, half Gram stain was done to demonstrate H. pylori. The organisms could be identified cytologically in 98% brush smears and 89% imprint smears when these were present in corresponding biopsy specimens. The overall diagnostic accuracy, sensitivity and specificity of brush cytology was 98% as compared to that of 91%, 80% and 97% respectively of imprint cytology. The organisms were not found in cases of gastric carcinomas and intestinal metaplasia. The study highlights the efficacy of brush cytology in detection of H.pylori which is a rapid and reliable method and is better than imprint cytology.
[ABSTRACT]   Full text not available  [PDF]
  161 2 -
Subcutaneous granulocytic sarcoma in the chest wall diagnosed by fine needle aspiration cytology -- A case report
Roque G W Pinto, Francisco Couto, Suresh Mandreker, Sachin Palyenkar, Lata Kamat
January-March 1995, 12(1):69-71
A case of Granulocytic sarcoma (Chloroma, Myeloblastoma) presenting as an isolated subcutaneous swelling on the anterior aspect of the chest wall in a 20 year old male is described. The diagnosis was made from the examination of a FNA biopsy specimen. The patient showed no peripheral blood or bone marrow evidence of leukemia at the time of presentation. However he developed Acute Myeloid leukemia four months later.
[ABSTRACT]   Full text not available  [PDF]
  162 0 -
Aspiration cytologie diagnosis of sinus histiocytosis with massive lymphadenopathy -- A case report with review of literature
Shyama Jain, Pritam L Dhingra
January-March 1995, 12(1):72-76
Present article reports a case of Sinus Histicytosis with Massive Lymphadenopathy diagnosed by fine needle aspiration cytology, where the clinical diagnosis of lymphoma was suspected. The classical cytological features are sheets of benign proliferating histiocytes in a polymorphous background and lymphophagocytosis. Review of the literature and emphasis on cytohistological features are discussed.
[ABSTRACT]   Full text not available  [PDF]
  162 0 -
Imprint cytology correlation with histopathology
S Radha Sagar, Suguna Ram Mohan, R Ashok Kumar
January-March 1995, 12(1):34-36
The aim of this study is to evaluate the accuracy of imprint cytology in diagnosis of benign & malignant neoplastic conditions in various organs. Alcohol fixed slides were stained by rapid H & E stain. A total number of 52 cases were studied. There were 22 benign lesions and 30 malignant lesions with equal distribution in various-organs. The rate of correlation is better in malignant (90%), than in benign lesions (82.6%). Imprint cytology is extremely useful as a rapid diagnostic technique with high sensitivity and specificity.
[ABSTRACT]   Full text not available  [PDF]
  156 1 -
Microfilariae of wuchereria bancrofti in fine needle aspirate from a subcutaneous cystic swelling - A case report
Dev Prasoon
January-March 1995, 12(1):80-81
Microfilarie of W. bancrofti were detected by fine needle aspiration cytology (FNAC) in a subcutaneous cystic swelling of the left forearm in a 30 years old female. Haemogram revealed 12% eosinophils. However, consecutive three night blood samples did not reveal microfilaria. Thus, FNAC was helpful in diagnosing an unsuspected case of filariasis without microfilaraemia.
[ABSTRACT]   Full text not available  [PDF]
  155 0 -
Role of colposcopy in cervical lesions
Maya Lulla, Ketki Shah, Laxmi Shah, Nidhi Kumar
January-March 1995, 12(1):42-47
This study was done to assess the role of colposcopy in inflammatory lesions cervical cancers and their recurrence and residual tumours. 180 cases were subjected to colposcopy and then cytology and target punch biopsies wherever required. As a result of the study it was found that cytology and colposcopy co-relate well at the 2 extremes of pathological findings and co-relation was 90.90% and co-relation between colposcopy and target punch biopsy was 86.6%. The conclusion drawn was that colposcopy should be done in women with abnormal cytology reports or with abnormal p/s findings. Colposcopy is helpful in determing the most abnormal area. For a target punch biopsy and a non-incastive or a minimally invastive lesion can be visualised by colposcopy. Also cytology, colposcopy and histopathology are to be used in co-relation with each other to derive the most accurate diagnosis of a lesion.
[ABSTRACT]   Full text not available  [PDF]
  151 3 -
Fine needle aspiration cytology in diagnosis of malignant lung lesions
Kamala P Singh, Alka Sharma, Narendra N Khanna
January-March 1995, 12(1):25-28
Transthoracic FNAC is direct approach to the diagnosis of pulmonary neoplasm. Our study emphasises the accuracy and simplicity of the technique with 60 (among 72) positive cases of carcinoma diagnosed without a complication. The diagnostic accuracy was 66.67% as a whole, however, it was significantly higher 85.2% in peripherally situated tumors. The procedure can be utilized on an outpatient basis obvitating the need of costly and relatively risky procedures. It can save valuable time and permit prompt institution of appropriate therapy.
[ABSTRACT]   Full text not available  [PDF]
  154 0 -
Immunocytochemistry of malignant effusions
Mithilesh Chandra
January-March 1995, 12(1):9-13
Immunocytochemistry analysis was carried out on 5 effusion fluids using Cytokeratin, Epithelial membrane antigen, Carcinoembryonic antigen and Vimentin. Cytokeratin was positive in all the cases including one case of mesothelioma. Epithelial membrane antigen staining was cytoplasmic in carcinomas but showed thick membranous staining with spiky projections in the case of mesothelioma. Carcinoembryonic antigen was negative in mesothelioma and prostatic carcinoma. Vimentin did not help in distinguishing carcinoma from mesothelioma.
[ABSTRACT]   Full text not available  [PDF]
  147 1 -
Polymerase chain reaction
Prakash V Patil
January-March 1995, 12(1):1-1
Full text not available  [PDF]
  81 0 -
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