Journal of Cytology
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Year : 2013  |  Volume : 30  |  Issue : 1  |  Page : 46-48

A case of pancreatic ductal adenocarcinoma with marked infiltration with IgG4-positive cells

1 Department of Pathologic Oncology, Institute of Molecular and Experimental Medicine, Faculty of Medicine, Mie University Graduate School of Medicine, Japan
2 Department of Pathology, Faculty of Pharmaceutical Science, Suzuka University of Medical Science, Japan

Correspondence Address:
M Yoneda
2 - 174 Edobashi, Tsu, Mie 514 - 8507
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-9371.107513

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A 75-year-old man was diagnosed as having pancreatic ductal carcinoma containing remarkable lymphocytic and plasma cell infiltration, as revealed by the cytological examination of endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) specimen. The EUS-FNA specimen showed small amounts of atypical epithelium with noticeable lymphocytes and plasma cells. A pancreatic resection was performed, and the histopathological features showed an invasive pancreatic ductal carcinoma with autoimmune pancreatitis (AIP) lymphoplasmacytic sclerosing pancreatitis (LPSP)-like lesions. Most of the plasma cells were immunoreactive to anti-IgG4 antibody. EUS-FNA may be necessary for the differential diagnosis of AIP and pancreatic cancer, and close attention should be given to the presence of marked lymphoplasmacytic cells in EUS-FNA specimens while making the diagnosis.

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