Journal of Cytology
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CASE REPORT
Year : 2010  |  Volume : 27  |  Issue : 4  |  Page : 152-154

Cytologic picture of Castleman's disease: A report of two cases


1 Consultant Pathologist, Medwin Hospitals, Hyderabad, India
2 Department of Pathology, Osmania Medical College, Hyderabad, India

Correspondence Address:
Ayyagari Sudha
Srigiri, 16-11-16/M/38, East Prashant Nagar, Moosarambagh, Malakpet, Hyderabad - 500036
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9371.73306

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Castleman's disease (CD), also called giant lymph nodal hyperplasia, is a lymphoproliferative disorder secondary to lymphoid follicle hyperplasia and marked capillary proliferation with endothelial hyperplasia. It presents as enlarged lymph nodes in the mediastinum, neck, groin, axilla and other sites. On clinical examination as well as gross examination, this disease mimics lymphomas and tuberculosis. Since cytological appearances vary depending on the type and extent of hyperplasia, fine needle aspiration cytology (FNAC) findings may not always be conclusive in all cases. We studied aspirates in two cases of CD, one of which presented with multiple enlarged axillary lymph nodes and the other with enlarged cervical lymph node. Cytology revealed reactive lymphadenitis with hyalinized capillaries and other features. Lymph node excision in both cases confirmed the diagnosis.


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