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Role of AgNOR in clinically suspicious prostatic nodule on cytology
AK Verma1, VK Sharma2, D Bisht3, AK Agarwal2, MD Tripathi4
1 Resident, Department of Pathology and Microbiology, L.L.R.M. Medical College, Meerut, Uttar Pradesh, India
2 Professor, Department of Pathology and Microbiology, L.L.R.M. Medical College, Meerut, Uttar Pradesh, India
3 Professor and Head, Department of Pathology and Microbiology, L.L.R.M. Medical College, Meerut, Uttar Pradesh, India
4 Professor and Head, Department of Surgery, L.L.R.M. Medical College, Meerut, Uttar Pradesh, India
Correspondence Address:
V K Sharma
Professor, Department of Pathology & Microbiology, L.L.R.M. Medical College, Meerut, Uttar Pradesh, Pin-250 004
India
 Source of Support: None, Conflict of Interest: None  | Check |
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Proliferative marker like argyrophilic nucleolar organizing regions (AgNOR) is of greater help for tumour analysis. It is especially valuable as an addition to classic prostate cytology and positive serological finding. Thirty six clinically, serologically and cytologically suspicious cases were subjected to AgNOR counting. The study revealed AgNOR counts of 2.93±0.40/cell in BPH, 3.84±0.44/cell in BPH with chronic prostatitis, 4.98±0.72/cell in grade I adenocarcinoma, 7.26±0.76/cell in grade II adenocarcinoma and 10.98±1.64 / cell in grade III adenocarcinoma. When combined with serological studies, evaluation of AgNOR score is of great help in distinguishing not only benign and malignant lesions of prostate but also low grade and high grade tumours. Finally, it was concluded that FNAC should be reserved for early diagnosis of prostate cancer in patients presenting with nonspecific urologic symptoms, palpable nodule and elevated serum PSA level.
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