Journal of Cytology
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ORIGINAL ARTICLE
Year : 2002  |  Volume : 19  |  Issue : 2  |  Page : 81-84

DNA aneuploidy in relation to tumor diathesis in cervical neoplasia


1 Senior Research Officer, Division of Cytopathology, Institute of Cytology and Preventive Oncology (ICMR), Maulana Azad Medical College Campus, Bahadur Shah Zafar Marg, New Delhi, India
2 Deputy Director, Division of Cytopathology, Institute of Cytology and Preventive Oncology (ICMR), Maulana Azad Medical College Campus, Bahadur Shah Zafar Marg, New Delhi, India

Correspondence Address:
Veena Kashyap
Sr. Research Officer, Institute of Cytology and Preventive Oncology, Maulana Azad Medical College Campus, Bahadur Shah, Zafar Marg, New Delhi
India
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Source of Support: None, Conflict of Interest: None


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Cytologically diagnosed Pap smear of sixty cases comprising of cervical intraepithelial neoplasia were reviewed to identify and grade the presence of tumor diathesis. The smears were classified into pattern I -where tumor diathesis was remarkable, present from nearly one end of the smear to the other, and with nebulous morphology of cells, pattern II - diathesis was minimal and morphology of cell was better preserved, pattern III - smears without tumor diathesis. Smears were subjected to DNA ploidy analysis. Pattern I was observed in twenty (33%) cases, pattern II in 17(28.3%) and pattern III in 23 (38.3%) cases. Amongst them, aneuploid DNA pattern was revealed in 15/20 (75%) pattern I, 11/17 (64.1%) pattern II and 15/23 (65.1%) pattern III. From the results, a decreasing trend of aneuploid DNA pattern was observed from pattern I to pattern II and III.


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