| ORIGINAL ARTICLE |
|
| Year : 2002 | Volume
: 19
| Issue : 1 | Page : 49-52 |
|
|
Langerhan's cell histiocytosis - The diagnostic problems by FNAC
Aparna Bhattacharya, Madhaumitha Mukhertee, Manimala Roy, Sulekha Das, Abhijit Banerjee, Anup Roy, Mamata Guha Mallik, Sabitri Sanyal, Dipanwita Nag, Swapan Sinha
Department of Pathology, Medical College, Calcutta-700 071, & Dr. Subodh Mitra Memorial Hospital & Research Centre, Calcutta-700 091, India
Correspondence Address:
Sabitri Sanyal
HB-122, Sector-III, Salt Lake City, Calcutta - 700 091
India
 Source of Support: None, Conflict of Interest: None  | Check |
|
|
FNAC smears from 19 selected cases of lytic lesions of bone which were clinically, radiologically and histogically confirmed to he Langerhans cell histiocytosis were selected for study of cell population by differential count in the smear. Radiologically two types of lesions were observed, lytic lesion and lytic lesion with sclerotic border (aged lesion). The differential count revealed a predominance of eosinophils closely followed by neutrophils; mononuclear giant cells with nuclei like that of Langerhans cells comprised 10% only, though this cell is the characteristic cell for Langerhans cell histiocytosis. A correlative differential count in two radiological types (lytic lesion and the lytic lesion with sclerotic border) revealed that lytic lesions were more densely populated by eosinophils against the aged lesions having more of neutrophils, multinucleated giant cells and foamy giant cell. Thus the diagnostic problem by FNAC arises when one observes :
- the neutrophil cell population exceeds the eosinohpil population.
- scanty mononuclear giant cells, and more of foamy giant cells.
FNAC findings need to be correlated with clinical and radiological findings to arrive at a diagnosis, in absence of special stains and EM facility.
|
|
|
|
| [PDF]* |
|
 |
|
