Journal of Cytology
Home About us Ahead of print Instructions Submission Subscribe Advertise Contact e-Alerts Login 
Users Online:119
  Print this page  Email this page Small font sizeDefault font sizeIncrease font size
Year : 2002  |  Volume : 19  |  Issue : 1  |  Page : 49-52

Langerhan's cell histiocytosis - The diagnostic problems by FNAC

Department of Pathology, Medical College, Calcutta-700 071, & Dr. Subodh Mitra Memorial Hospital & Research Centre, Calcutta-700 091, India

Correspondence Address:
Sabitri Sanyal
HB-122, Sector-III, Salt Lake City, Calcutta - 700 091
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

FNAC smears from 19 selected cases of lytic lesions of bone which were clinically, radiologically and histogically confirmed to he Langerhans cell histiocytosis were selected for study of cell population by differential count in the smear. Radiologically two types of lesions were observed, lytic lesion and lytic lesion with sclerotic border (aged lesion). The differential count revealed a predominance of eosinophils closely followed by neutrophils; mononuclear giant cells with nuclei like that of Langerhans cells comprised 10% only, though this cell is the characteristic cell for Langerhans cell histiocytosis. A correlative differential count in two radiological types (lytic lesion and the lytic lesion with sclerotic border) revealed that lytic lesions were more densely populated by eosinophils against the aged lesions having more of neutrophils, multinucleated giant cells and foamy giant cell. Thus the diagnostic problem by FNAC arises when one observes :
  • the neutrophil cell population exceeds the eosinohpil population.
  • scanty mononuclear giant cells, and more of foamy giant cells.
FNAC findings need to be correlated with clinical and radiological findings to arrive at a diagnosis, in absence of special stains and EM facility.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded15    
    Comments [Add]    

Recommend this journal