Journal of Cytology
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ORIGINAL ARTICLE
Year : 2000  |  Volume : 17  |  Issue : 3  |  Page : 141-147

Comparative evaluation of nuclear grading in FNAC Smears and tissue sections in cases of carcinoma breast


1 Professor and Head, Department of Pathology, B.R.D. Medical College, Gorakhpur, India
2 Associate Professor, Department of Pathology, B.R.D. Medical College, Gorakhpur, India
3 Junior Resident, Department of Pathology, B.R.D. Medical College, Gorakhpur, India

Correspondence Address:
R K Misra
Associate Professor, Department of Pathology, B.R.D. Medical College, Gorakhpur - 273 013. U.P
India
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Source of Support: None, Conflict of Interest: None


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Cytological grading of FNAC smears of breast carcinoma allows assessment of biological aggressiveness of tumour in situ, assisting in preoperative planning of treatment regime including the use of neoadjuvant chemotherapy. Nuclear grading was effected in accordance with Fisher's modification of Black's grading scheme. Using similar criteria forgrading cytologic smears and tissue specimens, independent blind grading of the two, revealed concurrence of nuclear grade assignment in 96% of the cases. Aspiration smear pattern and nuclear grade were found to be associated. There was maximum prevalence of typical pattern (sheets and clusters) in grade I cases, while of cluster predominance in grade II and III cases. Only grade III cases had individual cell pattern. There was a strong correlation between nuclear diameter and nuclear grade in cytologic smears. All cases of nuclear grade I were of small nuclear type, while 75% of grade II and all of grade III cases were of large nuclear type. Since nuclear grade provides important prognostic information, is simple to perform and correlates with tissue nuclear grade, it should appear in FNAC reports on ductal breast carcinomas.


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