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  Indian J Med Microbiol
 

Figure 1: Langerhans cell histiocytosis (a) Cytological smear showing Langerhans cells (LCs) with a few binucleate and multinucleate forms in a polymorphic infiltrate with a preponderance of eosinophils (MGG, ×100) (b) Aspirate smear showing LCs with grooved folded nuclei (arrows) (H and E, ×400) (c) An occasional LC showing mitosis (arrow) (H and E, ×200) (d) Histological section showing diffuse infiltration by sheets of LCs (H and E, ×400). Inset shows nuclear and cytoplasmic positivity for S-100 immunostain in LCs (Immunoperoxidase, ×400)

Figure 1: Langerhans cell histiocytosis (a) Cytological smear showing Langerhans cells (LCs) with a few binucleate and multinucleate forms in a polymorphic infiltrate with a preponderance of eosinophils (MGG, ×100) (b) Aspirate smear showing LCs with grooved folded nuclei (arrows) (H and E, ×400) (c) An occasional LC showing mitosis (arrow) (H and E, ×200) (d) Histological section showing diffuse infiltration by sheets of LCs (H and E, ×400). Inset shows nuclear and cytoplasmic positivity for S-100 immunostain in LCs (Immunoperoxidase, ×400)