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  Indian J Med Microbiol
 

Figure 1: Physical state HPV-16 DNA and expression of cyclin A and E; (a) Specimen NSIL, showing normal cells that presented as an episomal pattern (black arrow); (b) Specimen LSIL showing cells with karyomegaly presented as an integrated pattern (black arrow); (c) Positive for cyclin A expression, cells intermediate with karyomegaly (black arrows); (d) Expression of cyclin E positive, cells intermediate with binucleation and karyomegaly (black arrows). (Technique: In situ hybridization with tyramide amplification, × 400 and × 1000; Streptavidin biotin peroxidase, × 400)

Figure 1: Physical state HPV-16 DNA and expression of cyclin A and E; (a) Specimen NSIL, showing normal cells that presented as an episomal pattern (black arrow); (b) Specimen LSIL showing cells with karyomegaly presented as an integrated pattern (black arrow); (c) Positive for cyclin A expression, cells intermediate with karyomegaly (black arrows); (d) Expression of cyclin E positive, cells intermediate with binucleation and karyomegaly (black arrows). (Technique: <i>In situ</i> hybridization with tyramide amplification, × 400 and × 1000; Streptavidin biotin peroxidase, × 400)