Journal of Cytology

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 36  |  Issue : 4  |  Page : 200--204

Thyroid bethesda atypia of undetermined significance or follicular lesion of undetermined significance (aus/flus): A heterogenous group


Priyanka Maity1, Ashish Kumar Jha1, Moumita Sengupta1, Keya Basu1, Uttara Chatterjee1, Sujoy Ghosh2 
1 Department of Pathology, Institute of Postgraduate Medical Education and Research, Calcutta Medical College, Kolkata, West Bengal, India
2 Department of Endocrinology, Institute of Postgraduate Medical Education and Research, Calcutta Medical College, Kolkata, West Bengal, India

Correspondence Address:
Dr. Moumita Sengupta
Flat No – A11, Snehaneer Apartment, 1185 Chakgaria, Kolkata - 700 094, West Bengal
India

Background: The Bethesda system of reporting thyroid cytopathology (BSRTC) was introduced in 2007. The third category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) poses difficulties for the pathologist, and different papers have been published varying the risks of malignancy. Aims: (1) Evaluation of the cytological features of thyroid lesions according to BSRTC. (2) After resection, correlation with histopathological report to evaluate the risk of malignancy (ROM) and the risk of neoplasm (RON). (3) Division of category III into six subgroups based on cytological findings and assessment of ROM and RON. Materials and Methods: A total of 282 patients with diagnosed thyroid lesions underwent fine-needle sampling under ultrasound guidance. Smears were prepared and stained with May–Grunwald–Giemsa stain and Papanicolaou stain. Results: Of 282 cases, there were 9 cases (3.1%) of category I, 157 cases (55.8%) of category II, 24 cases (8.5%) of category III, 20 cases (7.1%) of category IV, 14 cases (4.8%) of category V, and 58 cases (20.7%) of category VI. The RON was 60, 17.1, 63.1, 77.7, 91.7, and 98.2% and the ROM was 60, 14.3, 26.3, 38.9, 91.7, and 96.3% in categories I, II, III, IV, V, and VI, respectively. The RON was 0, 75, 50, 100, 66.6, and 100% and the ROM was 0, 25, 50, 100, 16.6, and 0% in subgroups 1, 2, 3, 4, 5, and 6, respectively. We have proposed a system of subgrouping AUS/FLUS that may help to dispel the confusion generated by an AUS/FLUS report, and provide with a more exact and reproducible diagnostic and prognostic tool.


How to cite this article:
Maity P, Jha AK, Sengupta M, Basu K, Chatterjee U, Ghosh S. Thyroid bethesda atypia of undetermined significance or follicular lesion of undetermined significance (aus/flus): A heterogenous group.J Cytol 2019;36:200-204


How to cite this URL:
Maity P, Jha AK, Sengupta M, Basu K, Chatterjee U, Ghosh S. Thyroid bethesda atypia of undetermined significance or follicular lesion of undetermined significance (aus/flus): A heterogenous group. J Cytol [serial online] 2019 [cited 2019 Nov 12 ];36:200-204
Available from: http://www.jcytol.org/article.asp?issn=0970-9371;year=2019;volume=36;issue=4;spage=200;epage=204;aulast=Maity;type=0