Journal of Cytology

CASE REPORT
Year
: 2017  |  Volume : 34  |  Issue : 2  |  Page : 121--124

Littoral cell angioma of the spleen: Cytological findings and review of the literature


Mohammad H Anbardar1, Perikala V Kumar1, Hamid R Forootan2 
1 Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Pediatric Surgery, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence Address:
Mohammad H Anbardar
Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz
Iran

Littoral cell angioma (LCA) is a unique lesion of the spleen that arises from the cells lining the venous sinuses of the splenic red pulp and shows the features of combined endothelial and histiocytic differentiation. Several cases of LCA have been reported in the literature; however, the cytological findings have been described for only a few cases. We report the case of an 11-year-old boy with anemia, epigastric abdominal pain, and splenomegaly. The splenic lesions showed anastomosing vascular channels with cyst-like spaces filled by many sloughed endothelial cells, which were positive for CD68 and CD31 and negative for CD34. Scraping cytology revealed isolated and clusters of three-dimensional bland looking, epithelioid foamy tumoral cells with low nuclear cytoplasmic ratio, which mostly contained intracytoplasmic hemosiderin pigment. Although the fine needle aspiration cytology of splenic lesions is uncommon and LCA is a rare splenic lesion, it must be noted in the differential diagnosis of any splenic vascular neoplasm.


How to cite this article:
Anbardar MH, Kumar PV, Forootan HR. Littoral cell angioma of the spleen: Cytological findings and review of the literature.J Cytol 2017;34:121-124


How to cite this URL:
Anbardar MH, Kumar PV, Forootan HR. Littoral cell angioma of the spleen: Cytological findings and review of the literature. J Cytol [serial online] 2017 [cited 2020 Feb 25 ];34:121-124
Available from: http://www.jcytol.org/article.asp?issn=0970-9371;year=2017;volume=34;issue=2;spage=121;epage=124;aulast=Anbardar;type=0