Year : 2017 | Volume
: 34 | Issue : 1 | Page : 5--9
Evaluation of thyroid nodules classified as Bethesda category III on FNAC
Shiwani Garg, Leena P Naik, Kanchan S Kothari, Gwendolyn C Fernandes, Mona A Agnihotri, Jagruti C Gokhale
Department of Pathology, Seth G.S.M.C. and KEM Hospital, Mumbai, Maharashtra, India
Background: The Bethesda (BSRTC) category III has been ascribed a malignancy rate of 5-15%, however, the probability of malignancy remains variable.
Aim: To evaluate category III with respect to its rate and risk of malignancy and substratify it.
Settings and Design: Atypia of undetermined significance/Follicular lesion of undetermined significance (AUS/FLUS) percentage, cytohistological correlation, and risk of malignancy were analyzed and substratification was done.
Material and Methods: Category III cases over a 2-year period were analyzed retrospectively.
Statistical Analysis: Two-tailed Fisher exact test, with a level of significance set at 0.05, was performed for data analysis.
Results: Of 1169 thyroid fine needle aspirations (FNAs), 76 (6.5%) were category III. A total of 48 patients had follow up; 24 patients underwent surgery, 12 repeat FNA, and 12 were clinically followed. Repeat FNA cytology was unsatisfactory in 8.3%, benign in 66.7%, AUS in 8.3%, and follicular neoplasm in 16.7%. Of the 24 operated, 8 (33.3%) were malignant (follicular variants of papillary thyroid carcinoma), 5 (20.8%) were follicular adenomas, and 11 (45.8%) were non-neoplastic. Among all AUS/FLUS nodules with follow-up, malignancy was confirmed in 16.7% (8/48) whereas with nodules triaged to surgery only, the malignancy rate was 33.3% (8/24). Substratification into categories of «DQ»cannot exclude PTC«DQ» and «DQ»favor benign«DQ» helped detect malignancy better, as 85.7% cases in the first subcategory (P < 0.001) and none (P < 0.02) in the last proved malignant.
Conclusion: Though the rate of Category III in our study is in accordance to BSRTC, the risk of malignancy in AUS/FLUS nodules is higher. Substratification of AUS/FLUS may help better patient management.
Flat No. 105, M2B, Pratiksha Nagar, Sion (east), Mumbai - 400 022, Maharashtra
|How to cite this article:|
Garg S, Naik LP, Kothari KS, Fernandes GC, Agnihotri MA, Gokhale JC. Evaluation of thyroid nodules classified as Bethesda category III on FNAC.J Cytol 2017;34:5-9
|How to cite this URL:|
Garg S, Naik LP, Kothari KS, Fernandes GC, Agnihotri MA, Gokhale JC. Evaluation of thyroid nodules classified as Bethesda category III on FNAC. J Cytol [serial online] 2017 [cited 2017 Jul 27 ];34:5-9
Available from: http://www.jcytol.org/article.asp?issn=0970-9371;year=2017;volume=34;issue=1;spage=5;epage=9;aulast=Garg;type=0