Journal of Cytology

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 30  |  Issue : 2  |  Page : 87--93

Comparative evaluation of six cytological grading systems in breast carcinoma


Kaushik Saha1, Gargi Raychaudhuri2, Bitan Kumar Chattopadhyay3, Indranil Das1 
1 Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, India
2 Department of Pathology, College of Medicine and Sagore Dutta Hospital, Kolkata, India
3 Department of Surgery, Institute of Post Graduate Medical Education and Research, Kolkata, India

Correspondence Address:
Kaushik Saha
42/9/2, Sashi Bhusan Neogi Garden Lane, Baranagar, Kolkata - 700 036
India

Background: Cytological grading is a useful tool for selection of therapy and prognosis in breast carcinoma. Despite having many cytological grading systems, there is still no agreement among pathologists to accept one of them as a gold standard. Aim: This study was undertaken to evaluate six such three-tier cytological grading systems to determine which system corresponds best to histological grading done by Nottingham modification of Scarff Bloom Richardson (SBR)俟Q製 method. Materials and Methods: In a double-blind study, preoperative cytological grades obtained by six systems on fine-needle aspiration cytology (FNAC) smears were compared by testing concordance, association and correlation with histological grade derived postoperatively by the SBR俟Q製 method in 57 patients of breast carcinoma. Bivariate correlation studies and multiple linear regressions were done to assess the significance of the different cytological parameters to predict final cytological grades. Results: Robinson俟Q製 system demonstrated the best correlation (ρ = 0.799; P = 0.000 and τ = 0.765; P = 0.000), maximum percent agreement (77.19%) and a substantial kappa value of agreement (κ = 0.62) with the SBR俟Q製 grading system. All the six cytological grading systems correlated with histological grading strongly and positively. In multiple regression analysis, all of the cytological parameters of Robinson俟Q製 system except cell size and nucleoli had significance in predicting the final cytological grade. Conclusions: Robinson俟Q製 grading system is simple, more objective and reproducible, and demonstrated the best concordance with histological grading. So, Robinson俟Q製 system should be used routinely for breast carcinoma aspirates.


How to cite this article:
Saha K, Raychaudhuri G, Chattopadhyay BK, Das I. Comparative evaluation of six cytological grading systems in breast carcinoma.J Cytol 2013;30:87-93


How to cite this URL:
Saha K, Raychaudhuri G, Chattopadhyay BK, Das I. Comparative evaluation of six cytological grading systems in breast carcinoma. J Cytol [serial online] 2013 [cited 2019 Sep 23 ];30:87-93
Available from: http://www.jcytol.org/article.asp?issn=0970-9371;year=2013;volume=30;issue=2;spage=87;epage=93;aulast=Saha;type=0