Journal of Cytology

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 29  |  Issue : 2  |  Page : 121--124

Cytohistological correlation of endocervical gland involvement with high-grade squamous intraepithelial lesions


G Kir1, MH Karabulut1, MS Yilmaz1, CS Topal1, A Gocmen2 
1 Department of Pathology, Umraniye Education and Research Hospital, Istanbul, Turkey
2 Department of Obstetrics and Gynecology, Umraniye Education and Research Hospital, Istanbul, Turkey

Correspondence Address:
G Kir
Sinpas Aqua Manors Sitesi D-18, Alemdag cd., Yukari Dudullu Umraniye, Istanbul
Turkey

Background: Diagnosis of endocervical glandular involvement by high-grade squamous intraepithelial lesion (HSIL-EGI) on Papanicolaou (Pap) smears can affect the clinical management of patients. Aim: The cytological criteria for the diagnosis of HSIL-EGI are described and the accuracy of this diagnosis was investigated. Materials and Methods: Seventeen patients diagnosed with HSIL-EGI and 40 patients with diagnosis of HSIL on Pap smears with follow-up cone or loop electrocautery excision procedure (LEEP) biopsies were included in the study. The following criteria were evaluated for the cytological diagnosis of HSIL-EGI: atypical cells with definite features of HSIL, three-dimensional atypical squamous cell clusters (TDCs) with attached benign endocervical epithelium, finger-like TDCs covered with intact epithelium on most sides, which represent the finger-like invaginations of the endocervical glandular area involved by HSIL, and the absence of cytological findings of in situ adenocarcinoma of the cervix. Results: On subsequent histopathological evaluation, 16 of 17 (94.1%) patients with a cytological diagnosis of HSIL-EGI and 17 of 40 (42.5%) patients with HSIL exhibited endocervical glandular involvement (P < 0.001, sensitivity: 48.5%, specificity: 95.8%, positive predictive value: 94.1%, negative predictive value: 57.5% and accuracy: 68.4%). Conclusion: Diagnosis of HSIL-EGI may be possible on Pap smears with a high positive predictive value and specificity but low sensitivity, possibly due to cytological sampling limitations. To clarify the results of the present study, more extensive studies with a particular emphasis on the sampling of the endocervical glandular area for cytological evaluation of the cervix are needed.


How to cite this article:
Kir G, Karabulut M H, Yilmaz M S, Topal C S, Gocmen A. Cytohistological correlation of endocervical gland involvement with high-grade squamous intraepithelial lesions.J Cytol 2012;29:121-124


How to cite this URL:
Kir G, Karabulut M H, Yilmaz M S, Topal C S, Gocmen A. Cytohistological correlation of endocervical gland involvement with high-grade squamous intraepithelial lesions. J Cytol [serial online] 2012 [cited 2020 Jul 6 ];29:121-124
Available from: http://www.jcytol.org/article.asp?issn=0970-9371;year=2012;volume=29;issue=2;spage=121;epage=124;aulast=Kir;type=0