Journal of Cytology
Home About us Ahead of print Instructions Submission Subscribe Advertise Contact e-Alerts Login 
Users Online:1293
  Print this page  Email this page Small font sizeDefault font sizeIncrease font size


 
 Table of Contents    
LETTER TO EDITOR  
Year : 2015  |  Volume : 32  |  Issue : 3  |  Page : 211-212
Endoscopic ultrasound-guided FNA: Emerging technique to diagnose hydatid cyst of pancreas


Department of Cytopathology, Medanta - The Medicity, Gurgaon, Haryana, India

Click here for correspondence address and email

Date of Web Publication9-Nov-2015
 

How to cite this article:
Sharma S, Sarin H, Guleria M, Agrawal K. Endoscopic ultrasound-guided FNA: Emerging technique to diagnose hydatid cyst of pancreas. J Cytol 2015;32:211-2

How to cite this URL:
Sharma S, Sarin H, Guleria M, Agrawal K. Endoscopic ultrasound-guided FNA: Emerging technique to diagnose hydatid cyst of pancreas. J Cytol [serial online] 2015 [cited 2020 Apr 4];32:211-2. Available from: http://www.jcytol.org/text.asp?2015/32/3/211/168908


Sir,

Primary pancreatic hydatid cyst is a rare entity; the presentation as an asymptomatic pancreatic space-occupying lesion is even rarer. Caused by Echinococcus granulosus, the disease is prevalent in the Mediterranean region, Africa, South America, Australia, and the Middle East. We report two cases of pancreatic hydatid cyst that presented as pancreatic mass.

The first case was of a 48-year-old man who was diagnosed with pancreatic space-occupying lesion since last 10 years, and was kept on a follow-up. The patient was asymptomatic. Ultrasound showed a pancreatic cyst suggestive of infective etiology. Subsequently, an endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) was done.

The second case was of a 35-year-old woman who presented with a history of low-grade fever since 2 months, and ultrasound showed a pancreatic cystic mass.

Microscopic examination of Giemsa stained smear of both the cases in low power examination showed a necrotic background with dispersed laminated membranes [Figure 1]a and b. On careful evaluation on higher power, there were hooklets and scolices. Scolices were seen with attached two rows of hooklets [Figure 1]c. These were also appreciated in periodic acid-Schiff (PAS) and Grocott silver stains [Figure 1]c and d, [Figure 2]a and b. Additionally, Ziehl-Neelsen (ZN) and PAS stain tests were done to rule out the possibility of tuberculosis and any other fungal infection. A diagnosis of primary hydatid cyst of pancreas was given.
Figure 1 (Case 1): (a) Smear shows a necrotic background (Giemsa, ×100); (b) Laminated membrane of hydatid cyst. (Giemsa, ×400); (c) Scolex with rows of hooklets. (Gomori methnamine silver stain, ×1000); (d) Dispersed hooklets. (Periodic-acid Schiff stain, ×400)

Click here to view
Figure 2 (Case 2): (a) Monolayered epithelial sheets with mucin. (Periodicacid Schiff stain, ×400); (b) Hooklets attached to mucin lakes. (Periodic-acid Schiff stain, ×1000)

Click here to view


There are only two cases of cytological diagnosis of hydatid cyst in pancreas reported in indexed journals. We report these two cases to highlight the importance of EUS-guided FNAC in diagnosing infective cystic lesion that mimic a neoplastic process otherwise.

Hydatid cyst is an infective disease of humans and animals seen more commonly in some specific geographic regions of the world. The primary route of human infection is the ingestion of E. granulosus eggs through consumption of vegetables that are contaminated with dog feces. While liver involvement is the most common manifestation, pancreatic hydatid cyst has been reported in 0.25-0.75% of the cases. [1] The head of the pancreas is the most common location (57%), followed by the corpus (24%) and the tail (19%). [2],[3] Possible sources of infestation include hematogenous dissemination, local spread via pancreaticobiliary ducts, and peripancreatic lymphatic invasion. [2],[3]

Preoperative diagnosis of pancreatic hydatid cyst is difficult as it may be mistaken for pseudocysts, cystadenocarcinoma, and congenital or post-traumatic cysts. [4] Hydatid cyst should be considered a differential diagnosis of pancreatic cystic lesions.

EUS has emerged as an effective technique to gain access to retroperitoneal organs such as pancreas. EUS-guided FNA has increased the probability to identify hydatid cyst in the pancreas that has been considered a rare site so far. This is an effective and safe procedure for diagnosing pancreatic lesions, be it malignant or benign. [5]

EUS findings alone has limitations regarding definitive diagnosis; however, fluid aspiration can help in differentiating malignant cystic lesions.

Cytological evaluation of EUS-guided FNA emerges as an important diagnostic tool, preventing unnecessary surgical intervention. Precaution for anaphylaxis and spread of protoscolices can be taken timely.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
   References Top

1.
Brown RA, Millar AJ, Steiner Z, Krige JE, Burkimsher D, Cywes S. Hydatid cyst of the pancreas - a case report in a child. Eur J Pediatr Surg 1995;5:121-3.  Back to cited text no. 1
    
2.
Ozmen MM, Moran M, Karakahya M, Coskun F. Recurrent acute pancreatitis due to a hydatid cyst of the pancreatic head: A case report and review of the literature. JOP 2005;6:354-8.   Back to cited text no. 2
    
3.
Jai SR, El Hattabi K, Bensardi F, Chehab F, Khaiz D, Bouzidi A. Primary hydatid cyst of the pancreas causing obstructive jaundice. Saudi J Gastroenterol 2007;13:191-3.   Back to cited text no. 3
[PUBMED]  Medknow Journal  
4.
Lemmer ER, Krige JE, Price SK, Girdwood AH. Hydatid cyst in the head of the pancreas with obstructive jaundice. J Clin Gastroenterol 1995;20:136-8.  Back to cited text no. 4
    
5.
Baghbanian M, Shabazkhani B, Ghofrani H, Forutan H, Dariani N, Farahvash M, et al. Efficacy of endoscopic ultrasound guided fine needle aspiration in patients with solid pancreatic neoplasms. Saudi J Gastroenterol 2012;18:358-63.  Back to cited text no. 5
[PUBMED]  Medknow Journal  

Top
Correspondence Address:
Shivani Sharma
Department of Cytopathology, Medanta - The Medicity, Sector 38, Gurgaon, Haryana
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9371.168908

Rights and Permissions


    Figures

  [Figure 1], [Figure 2]

This article has been cited by
1 Pancreatic echinococcosis
Priti Soin,Pranav Sharma,Puneet Singh Kochar
Baylor University Medical Center Proceedings. 2019; 32(1): 85
[Pubmed] | [DOI]
2 Primary hydatid cyst of pancreas: Case report and review of literature
Zeeshan Ahmed,Sanjeev Chhabra,Ashish Massey,Vikesh Vij,Rahul Yadav,Rajendra Bugalia,Jeevan Kankaria,Raj K. Jenaw
International Journal of Surgery Case Reports. 2016; 27: 74
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  


    References
    Article Figures

 Article Access Statistics
    Viewed1238    
    Printed16    
    Emailed0    
    PDF Downloaded75    
    Comments [Add]    
    Cited by others 2    

Recommend this journal