Journal of Cytology
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Year : 2015  |  Volume : 32  |  Issue : 2  |  Page : 132-135

Transthoracic fine-needle aspiration cytology of non-invasive, low-grade urothelial carcinoma with lung metastasis: A case report with review of the literature

1 Department of Pathology, Kocaeli University, Kocaeli, Turkey
2 Department of Medical Oncology, Kocaeli University, Kocaeli, Turkey
3 Department of horacic Surgery, Kocaeli University, Kocaeli, Turkey

Correspondence Address:
Çigdem Vural
Department of Pathology, Kocaeli University Faculty of Medicine, Kocaeli
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-9371.160572

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Radiological analyses in a 61-year-old patient being followed since 2005 for low-grade, non-invasive urothelial carcinoma (UC) (Ta) revealed a 5-cm pleural-based mass in the lower lobe of the right lung for which a subsequent transthoracic fine-needle aspiration cytology was performed. Upon observing the carcinoma cells consistent with UC metastasis, systemic chemotherapy was commenced. The patient underwent a metastatectomy based on the thoracic computerized tomography scan performed on the 4 th month of treatment, which revealed notable regression. The resected tumor was morphologically similar to cells seen in the transthoracic fine-needle aspiration and was immunohistochemically positive for p63, uroplakin, thrombomodulin, CK7 and CK20 at varying degrees but was negative for TTF-1. We report a case of metastatic UC of the lung in a patient who had had a low-grade superficial UC of the urinary bladder and we discuss the cytopathological features of this rare entity in light of the literature.

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