Journal of Cytology
Home About us Ahead of print Instructions Submission Subscribe Advertise Contact e-Alerts Login 
Users Online:886
  Print this page  Email this page Small font sizeDefault font sizeIncrease font size


 
 Table of Contents    
LETTER TO EDITOR  
Year : 2014  |  Volume : 31  |  Issue : 1  |  Page : 59-60
Renal oncocytoma: A diagnostic dilemma on cytology


Department of Pathology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India

Click here for correspondence address and email

Date of Web Publication15-Apr-2014
 

How to cite this article:
Biswas B, Wahal SP, Gulati A. Renal oncocytoma: A diagnostic dilemma on cytology. J Cytol 2014;31:59-60

How to cite this URL:
Biswas B, Wahal SP, Gulati A. Renal oncocytoma: A diagnostic dilemma on cytology. J Cytol [serial online] 2014 [cited 2020 Sep 22];31:59-60. Available from: http://www.jcytol.org/text.asp?2014/31/1/59/130717


Sir,

Renal oncocytoma is a rare, benign renal epithelial tumor composed of large cells with mitochondria-rich cytoplasm thought to arise from intercalated cells of the collecting duct. The cytological features of renal oncocytoma show overlapping with other renal entities. We report a case of renal oncocytoma along with its cytological features and its differentials.

A 78-year-old woman presented with dull aching pain in the left lumbar region since 2 years. On examination, a left renal mass was palpable. The computed tomography scan showed a well-defined heterogeneous mass measuring 4 × 4 cm with nonenhancing central scar in mid and lower left kidney [Figure 1]A. An ultrasound-guided fine needle aspiration (FNA) of the left renal mass was performed. The smears revealed cells arranged in loosely cohesive clusters. The cells were pleomorphic with low nucleo-cytoplasmic ratio, round nuclei, inconspicuous nucleoli, fine chromatin, and granular basophilic cytoplasm [Figure 1]B. A cytodiagnosis of renal cell carcinoma with possibility of renal oncocytoma, chromophobe renal cell carcinoma (ChRCC) and RCC - granular variant was suggested. A left radical nephrectomy was done and sent for histopathological examination. The nephrectomy specimen measured 9 × 6 × 3 cm with ureter measuring 5 cm in length. Cut surface showed a well-circumscribed subcapsular growth measuring 4 × 4 cm occupying the lower pole of the kidney. The cut surface of the growth was tan-brown to mahogany-brown in color [Figure 1]C. Microscopic examination of the growth revealed nests, alveoli, and balls of tumor cells, surrounded by myxoid and focally hyalinized stroma [Figure 1]D. At some places tumor cells were arranged in the organoid pattern surrounded by thin fibrovascular septae. The tumor cells had central round, mildly pleomorphic nuclei, small nucleoli, and abundant eosinophilic granular cytoplasm. Occasional cystically dilated glands lined by oncocytic cells and dilated congested vascular spaces were also seen. No necrosis, papillae formation, or mitotic activity was seen. The ureter and renal vessels were free from tumor invasion. The Hale's iron colloidal stain was negative in the tumor cells. A diagnosis of oncocytoma of the left kidney was given.
Figure 1: (a) The CT scan showing a 4 × 4 cm heterogeneous mass in mid and lower left kidney. (b) The cytosmears show loosely cohesive clusters of cells with low nucleocytoplasmic ratio, round nuclei, inconspicuous nucleoli, fi ne chromatin, and granular cytoplasm (Giemsa, x400). (c) Left nephrectomy specimen showing a circumscribed growth in the lower pole with mahogany-brown cut surface. (d) Nest of tumor cells with central round, mildly pleomorphic nuclei, small nucleoli and abundant eosinophilic granular cytoplasm separated by thin fi brovascular septae (H and E, x400)

Click here to view


Renal oncocytoma was first described by Zippel [1] and was largely ignored until the publication of 13 cases by Klein and Valensi. [2] Oncocytomas comprise 3% to 7% of all primary renal neoplasms. [3] Oncocytoma has a wide age distribution, with peak incidence in seventh decade of life, men are affected twice as commonly as females. [3] The tumor is asymptomatic in most of the cases and is discovered during work up for other causes. [4] Angiography reveals an avascular or hypovascular core, secondary to central stellate scar. The central scar is used to differentiate between renal cell carcinoma (RCC) from oncocytoma radiologically; however, accuracy is poor. The scar can also be seen in chromophobe RCC or conventional RCC. [5] Grossly, oncocytoma is subcapsular, encapsulated, cut surface is uniform, and mahogany-brown colored. They can be multicentric and bilateral. Invasion of renal vein or renal capsule can also be encountered. [6] A condition called oncocytosis is described in which there is the presence of innumerable oncocytic nodules in one or both the kidneys, usually associated with the presence of dominant nodule. Renal oncocytomas are composed of large cells with granular, abundant, eosinophilic cytoplasm devoid of vacuoles, supported by delicate fibrovascular septae. The nuclei are small, round, and uniform. The other renal tumors with similar morphology are ChRCC and RCC with predominant granular features. Out of all there tumors, oncocytomas have smallest nucleoli measuring 8-10 μm in diameter. Cytological features of renal oncocytoma were first described by Rodriguez [7] in 1980. The cytology consists of uniform population of large eosinophilic granular cells that are either isolated or form small, loose aggregates. The cell borders are well defined and nucleoli are quite small and round. The oncocytic cells in ChRCC and granular cell types of conventional RCC show significant nuclear abnormalities. The lipid and glycogen stains are negative in renal oncocytoma. The cells of ChRCC are positive for Hale's colloidal iron, which stains the cytoplasmic acid mucins. Conventional RCC show positivity for lipid and glycogen stains in some cells. Renal oncocytoma is reactive for immune stains EMA, low molecular keratin and negative for vimentin. It is differentiated immunogically from conventional RCC by vimentin positivity in the latter. Ultrastructurally, the cytoplasm of tumor cells is packed with mitochondria to the virtual exclusion of any organelles other than a few lysosomes. Thus, electron microscopy remains the gold standard for confirming this diagnosis.

The most common genetic abnormality is loss of chromosome 1 and Y, also seen in ChRCC. Both tumors are thought to arise from intercalated cells of the renal cortex, accounting for striking gross and microscopic similarities. A coexistence of ChRCC in the same or contralateral kidney of patients with oncocytoma has been reported in one series in as high as 32% cases. [8] In some cases, ChRCC is found buried within an oncocytoma. [9] Renal oncocytoma is a benign lesion; however, there have been reports that some tumors may invade the parenchyma of the kidney and may recur. [7] If strict diagnostic criteria are followed and the diagnosis of oncocytoma is limited to tumors composed exclusively of well-differentiated oncocytes with small nuclei, the prognosis is excellent and the tumor is considered to be benign. For tumors diagnosed as oncocytomas that produce metastasis, the possibility of misclassification should be considered.

We present this case to highlight the pitfalls in the diagnosis of renal oncocytoma on cytology and its differential diagnosis.

 
   References Top

1.Zippel L, Zur Kenninis der Onkocytonen, Virchows. Arch A Pathol Anat Histopathol 1942;308:360-82.  Back to cited text no. 1
    
2.Klein MJ, Valensi QJ. Proximal tubular adenomas of kidney with so-called oncocytic features. A clinicopathologic study of 13 cases of a rarely reported neoplasm. Cancer 1976;38:906-14.  Back to cited text no. 2
[PUBMED]    
3.Reuter VE, Gaudin PB. Adult renal tumors. In: Sternberg SS, editor. Diagnostic surgical pathology. Philadelphia: JB Lippincott; 1999. p. 1785-818.  Back to cited text no. 3
    
4.Perez-Ordonez B, Hamed G, Campbell S, Erlandson RA, Russo P, Gaudin PB, et al. Renal oncocytoma: A clinicopathologic study of 70 cases. Am J Surg Pathol 1997;21:871-83.  Back to cited text no. 4
    
5.Davidson AJ, Hayes WS, Hartman DS, McCathy WF, Davis CJ Jr. Renal oncocytoma and carcinoma. Failure of differentiation with CT. Radiology 1993;186:693-6.  Back to cited text no. 5
    
6.Kadesky KT, Fulgam PF. Bilateral multifocal renal oncocytoma. Case report and review of literature. J Urol 1993;150:1227-8.  Back to cited text no. 6
    
7.Rodriguez CA, Buskop A, Johnson J, Fromowitz F, Koss LG. Renal oncocytoma: preoperative diagnosis by aspiration biopsy. Acta Cytol 1980;24:355-9.  Back to cited text no. 7
[PUBMED]    
8.Licht MR, Novick AC, Tubbs AR, Klein EA, Levin HS, Streem SB. Renal oncocytoma. Clinical and biological correlate. J Urol 1993;150:1380-3.  Back to cited text no. 8
    
9.Davis CJ Jr, Sesterhenn IA, Mostofi FK, Ho CK. Renal oncocytoma. Clinicopathological study of 166 patients. J Urogen Pathol 1999;1:41-52.  Back to cited text no. 9
    

Top
Correspondence Address:
Shailja Puri Wahal
Department of Pathology, Indira Gandhi Medical College, Shimla - 171 001, Himachal Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9371.130717

Rights and Permissions


    Figures

  [Figure 1]

This article has been cited by
1 Renal oncocytoma: differential diagnosis and treatment
Yu. A. Stepanova,O. A. Chekhoeva,A. A. Teplov,A. A. Gritskevich,D. V. Kalinin
Onkologiya. Zhurnal imeni P.A.Gertsena. 2019; 8(2): 113
[Pubmed] | [DOI]
2 Assessment of multiphasic contrast-enhanced MR textures in differentiating small renal mass subtypes
Uyen N. Hoang,S. Mojdeh Mirmomen,Osorio Meirelles,Jianhua Yao,Maria Merino,Adam Metwalli,W. Marston Linehan,Ashkan A. Malayeri
Abdominal Radiology. 2018;
[Pubmed] | [DOI]
3 Bilateral benign renal oncocytomas and the role of renal biopsy: single institution review
Andrew R. Leone,Laura C. Kidd,Gregory J. Diorio,Kamran Zargar-Shoshtari,Pranav Sharma,Wade J. Sexton,Philippe E. Spiess
BMC Urology. 2017; 17(1)
[Pubmed] | [DOI]
4 Biomarkers of Renal Tumors: the Current State and Clinical Perspectives
Marina O. Golovastova,Dmitry O. Korolev,Larisa V. Tsoy,Vladimir A. Varshavsky,Wan-Hai Xu,Andrey Z. Vinarov,Evgeni Yu. Zernii,Pavel P. Philippov,Andrey A. Zamyatnin
Current Urology Reports. 2017; 18(1)
[Pubmed] | [DOI]
5 Renal cell carcinoma: Review of etiology, pathophysiology and risk factors
Nadezda Petejova,Arnost Martinek
Biomedical Papers. 2016; 160(2): 183
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  


    References
    Article Figures

 Article Access Statistics
    Viewed1854    
    Printed29    
    Emailed0    
    PDF Downloaded119    
    Comments [Add]    
    Cited by others 5    

Recommend this journal