Journal of Cytology
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ORIGINAL ARTICLE
Year : 2006  |  Volume : 23  |  Issue : 3  |  Page : 113-118

Morphometry of thyroid lesions with cytological and histological correlation


1 Post Graduate Trainee, Department of Pathology, IPGME & R, Kolkata, India
2 Lecturer, Department of Pathology, IPGME & R, Kolkata, India
3 Assistant Professor, Department of Pathology, IPGME & R, Kolkata, India
4 Associate Professor; Department of Pathology, IPGME & R, Kolkata, India

Correspondence Address:
A K Manna
D-17/14 Karunamoyee Housing Estate, Salt Lake, Kolkata, West Bengal, 700 091
India
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Source of Support: None, Conflict of Interest: None


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The study was done to evaluate the role of morphometry in various thyroid lesions with cytological and histological correlation. Cytology and histology of 100 cases of non-neoplastic, benign and malignant thyroid lesions were compared, together with the role of morphometric nuclear parameters with the aid of an ocular morphometer attached to the 6x eye-piece of a microscope using a 40x high-dry objective. Analysis of Variance (ANOVA) among definite adenomatoid goitre, suspicious lesions and definite follicular neoplasm as identified by FNAC and between non-neoplastic lesions, follicular neoplasm and other carcinomas in FNAC after histological correlation was highly significant (p<0.0001). ANOVA among nonneoplastic, benign and malignant in histology (p<0.0001) and t-test between Papillary carcinoma and follicular carcinoma in histology (p<0.0028) were also highly significant. Morphometry correlated with cytology and histology proved to be an extremely valuable tool in case of thyroid lesions increasing the sensitivity of FNAC from 59.09% to 82.61%, predictive value of negative test from 87.84% to 93.85%, accuracy rate from 89.66% to 95.24% and decreased the Percentage of false negative from 40.91% to 17.39%.


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