Journal of Cytology
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ORIGINAL ARTICLE
Year : 2006  |  Volume : 23  |  Issue : 1  |  Page : 18-23

Sonographically guided fine needle aspiration of hepatic neoplasms


1 Professor, Department of Pathology, JN Medical College, AMU, Aligarh 202 002, India
2 Reader, Department of Pathology, JN Medical College, AMU, Aligarh 202 002, India
3 Lecturer, Department of Pathology, JN Medical College, AMU, Aligarh 202 002, India
4 Jr Resident, Department of Pathology, JN Medical College, AMU, Aligarh 202 002, India
5 Reader, Department of Radiodiagnosis, JN Medical College, AMU, Aligarh 202 002, India, 202 002,

Correspondence Address:
N Khan
A-11 Medical Colony, AMU, Aligarh, Uttar Pradesh 202 002
India
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Source of Support: None, Conflict of Interest: None


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This study was aimed at determining the incidence of hepatic malignancy and evaluating the various morphological features that differentiate the metastatic adencarcinoma from hepatocellular carcinoma (HCC). Guided FNAC smears from 261 patients with USG evidence of focal/ diffuse hepatic lesions were examined for different cytomorphologic details. The commonest hepatic neoplasm was metastasis (63 out of 105 cases). On USG, metastsis (54 cases) commonly showed multiple nodules (>2 cm), while HCC appeared as solitary nodule in 23 out of 35 cases. With increasing size of the tumor, decreased cytological differentiation of HCC was observed. Cytology was able to correctly diagnose 103 out of 105 cases with an overall accuracy rate of 98%. The most significant cytological features to diagnose Aca were, acinar/ glandular/ papillary pattern of columnar to cuboidal cells with little cytoplasm with or without peripheral palisading and necrosis. While HCC was diagnosed by trabecular pattern of hepatocytic cells with eosinophilic granular cytoplasm, atypical stripped nuclei and bile pigment.


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