Journal of Cytology
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ORIGINAL ARTICLE
Year : 2004  |  Volume : 21  |  Issue : 2  |  Page : 82-84

Cytomorphological features of in-situ carcinoma of breast in fine needle aspiration cytology


1 Senior Resident, Department of Pathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
2 Associate Professor, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
3 Professor and Head, Department of Cytology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
4 Professor and Head, Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Correspondence Address:
Sanjib Kumar Pattari
Senior Resident, Department of Cytology, PGIMER, Chandigarh
India
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Source of Support: None, Conflict of Interest: None


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Fine needle aspiration cytology (FNAC) is an important tool in investigating palpable breast lesions. Its sensitivity and specificity are quite high in benign and malignant lesions. However carcinoma-in situ (CIS) cases are very difficult to diagnose in FNAC. CIS cases are frequently misdiagnosed. The aim of this present study is to compare various cytomorphological features to distinguish CIS and infiltrating ductal carcinoma (IDC) cases. Eight cases of CIS and 10 cases of IDC were taken for the study. Various cytomorphological features i.e. cellularity, cell dissociation, cell size, cell uniformity, nucleoli, nuclear margin, chromatin character, mitosis alongwith number of myoepithelial cells were compared in both groups. We noted that the cells of CIS cases were smaller in size, less pleomorphic with more regular nuclear margin and inconspicuous nucleoli than IDC cases. The number of myoepithelial cells was significantly higher in CIS cases than IDC cases. These features can be used to distinguish CIS and invasive ductal carcinomas.


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