Journal of Cytology
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ORIGINAL ARTICLE
Year : 2004  |  Volume : 21  |  Issue : 2  |  Page : 73-76

Spectrum of langerhans cell histocytosis with prognostic parameters


1 Professor and Head, Department of Pathology, Medical College, Kolkata, India
2 Assistant Professor, Department of Pathology, Medical College, Kolkata, India
3 Demonstrator, Department of Pathology, IPGME and R, Kolkata, India
4 Associate Professor, Department of Pathology, Medical College, Kolkata, India
5 Associate Professor, Department of Pathology, BS Medical College, Bankura, India
6 Ex Lecturer, Department of Pathology, IPGME and R, Kolkata, India

Correspondence Address:
Swapan Kr Sinha
B-IV-G-04, J-373, Nairit Appts. BG Patali, Kolkata 700 094
India
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Source of Support: None, Conflict of Interest: None


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Thirteen patients, eight males and five females, age ranging from 10 months to 24 years, presented with solitary lytic lesions in three cases (23%), more than one lytic bone lesions in two cases (15.38%) and disseminated disease with lytic bone lesions, lymphadenopathy, hepatosplenomegaly, endocrinopathy (diabetes insipidus), exophthalmos and skin lesion in eight cases (61.5%). FNA cytology was performed in all the cases and the diagnosis was Langerhans Cell Histiocytosis (LCH). Histological examination done in seven patients confirmed the diagnosis of LCH. CD la was done on tissue sections in four cases and three tested positive. Ten had anaemia (77%), two had leucopenia (15%), three had thrombocytopenia (23%) and one had pancytopenia (7.5%). Bone marrow was aspirated in six cases and involvement was present in two cases (all disseminated form of the disease). Prognostic parameters were evaluated on the basis of clinical, radiological, haematological and histological features.


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