Journal of Cytology
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ORIGINAL ARTICLE
Year : 1999  |  Volume : 16  |  Issue : 1  |  Page : 21-26

Exfoliative cytology of abnormal nipple discharge


1 Senior Resident, Department of Pathology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi - 110 003, India
2 Assistant Professor, Department of Pathology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi - 110 003, India
3 Professor, Department of Pathology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi - 110 003, India

Correspondence Address:
Shyama Jain
20/59, Lodhi Colony, New Delhi - 110 003
India
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Source of Support: None, Conflict of Interest: None


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The diagnostic utility of nipple discharge (ND) in different breast lesions was assessed retrospectively in 81 patients. The spectrum of diagnoses offered were : malignant (six), suspicious of malignancy (nine), benign cystic lesion (43), inflamator/ lesion ( 12), and inadequate (eight). Three cases were cytologically negative but had strong clinical suspicion for cancer. The frequency of milky discharge decreased and bloody discharge increased with age Sixty percent of the malignant and only 9-10% benign cases had bloody discharge. About86.67% of unilateral and 80% of single duct discharge were associated with carcinoma. In 21 cases with palpable lump FNAC was performed which confirmed diagnosis of duct carcinoma (DC) in eight, papillary lesion in four and fibrocystic disease in nine cases. Histological findings were correlated in nine cases. In two cases of ND without associated lump, cytology showed frank malignant cells. Histology of one of them confirmed the diagnosis of infiltrating duct carcinoma. Cytoiogical examination of ND is a non-invasive, simple and rapid technique. It is helpful in guiding the management of the patient specially in non palpable breast lesions.


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