Journal of Cytology
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CASE REPORT
Year : 1998  |  Volume : 15  |  Issue : 2  |  Page : 45-50

Diagnostic problem of reed-sternberg cells in a case of cns lymphoma


1 Assistant Professor, National Institute of Mental Health and Neurosciences, Bangalore, India
2 Associate Professor, National Institute of Mental Health and Neurosciences, Bangalore, India
3 Professor and Head, National Institute of Mental Health and Neurosciences, Bangalore, India
4 Professor, National Institute of Mental Health and Neurosciences, Bangalore, India

Correspondence Address:
S K Shankar
Professor and Head, Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore-560 029
India
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Source of Support: None, Conflict of Interest: None


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A case of diffuse, large cell Non Hodgkin's Lymphoma (NHL), with primary intracranial presentation is reported. Both intraoperative squash smears and histology were suggestive of Hodgkins disease (HD) due to the presence of Reed-Sternberg (RS) like cells in a background of small lymphocytes and histiocytes. However positivity of the RS like cells for leucocyte common antigen (CD45) indicated a diagnosis of NHL. This highlights the importance ofimmuno histochemistry in cytological evaluation, diagnosis and appropriate subtyping of lymphoma, particularly when there is potential for total cure of these neoplasms with specific chemotherapy.


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