Journal of Cytology
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ORIGINAL ARTICLE
Year : 1997  |  Volume : 14  |  Issue : 2  |  Page : 41-46

Cytologic grade and DNA studies in node-negative breast carcinoma


1 Associate Professor of Cytology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 Assistant Professor of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
3 Professor of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
4 Professor of Cytology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Raje Nijhawan
Associate Professor of Cytology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012
India
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Source of Support: None, Conflict of Interest: None


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This pilot study was performed on twenty two women suffering from node-negative breast carcinoma as diagnosed by Fine-Needle Aspiration Cytology, correlating cytological grade with DNA studies on the aspirates. The data suggested that with an increase in cytologic grade, there is a trend of a shift from diploidy to aneuploidy, and a rise in the S-phase fraction. All the four grade I tumours were diploid with a low S-phase fraction. All the six grade III tumours were aneuploid, four of which showed a high S-phase, one showed a low S-phase; and in one, S-phase could not be determined. In the twelve patients clustered in grade II, there, was an almost equal distribution of cases showing diploidy and aneuploidy, and of a low and high S-phase fraction. It is concluded that cytologic grading in conjunction with ploidy and S-phase on FNA samples of breast carcinomas could prove to be a useful prognostic marker, the validity of which needs to be ascertained by carying out similar studies on a large number of women suffering from breast carcinoma combined with long-term follow up.


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